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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T8861	GSK199	PAD	Chromatin/Epigenetic
	GSK199 是可逆的 PAD4选择性抑制剂，当缺少钙离子时，其 IC50值为 200 nM。
T22277	BMS-P5	PAD	Chromatin/Epigenetic
	BMS-P5 是一种特异性具有口服活性的肽精氨酸二亚胺酶 4抑制剂。它可阻断多发性骨髓瘤诱导的 NET 形成，并延缓肿瘤进程。
T24105	GSK121 GSK-121,GSK 121	PAD	Chromatin/Epigenetic
	GSK121 Trifluoroacetate 是PAD4的选择性抑制剂。
T22277L	BMS-P5 free base	PAD	Chromatin/Epigenetic
	BMS-P5 free base 是一种特异性，可口服的肽精氨酸二亚胺酶抑制剂，可阻断多发性骨髓瘤诱导的 NET 形成，并延缓肿瘤进程。
T10831L	Cl-amidine hydrochloride	Apoptosis; PAD	Apoptosis; Chromatin/Epigenetic
	Cl-amidine hydrochloride 是一种口服有效的PAD 抑制剂，可阻断组蛋白 3 瓜氨酸化和中性粒细胞胞外陷阱的形成，并提高败血症小鼠的存活率。它可诱导癌细胞凋亡，还可诱导 miR-16 引起细胞周期阻滞。
TQ0067	GSK484 hydrochloride GTPL8577,AOB6992,GSK484盐酸盐	PAD	Chromatin/Epigenetic
	GSK484 hydrochloride (GTPL8577) 是一种可逆的肽酰基精氨酸脱亚氨酶 4 (PAD4) 抑制剂。它高亲和力与 PAD4 结合，在存在 2 mM 钙和不存在钙的情况下，IC50分别为 250 和 50 nM。
T36107	YW3-56 YW3-56
	YW3-56 is a potent peptidylarginine deiminase (PAD) inhibitor, with an IC50 of 1-5 μM for PAD4. Compared with Cl-amidine, YW3-56 shows >60-fold increase in cell growth inhibition efficacy (IC50 about 2.5 μM) but only 5-fold increase in PAD4 inhibition (IC sub>50 about 1-5 μM). At 2-4 μM concentrations, YW3-56 displays mainly cytostatic effects by slowing cell division, whereas at higher concentrations, it exerts cytotoxic effects by altering cell morphology and killing cells[1]. [1]. Wang Y, et ...
T36108	YW3-56 (hydrochloride) (technical grade) YW3-56 (hydrochloride) (technical grade)
	YW3-56 is an inhibitor of protein arginine deiminase 2 (PAD2) and PAD4 (IC50s = 0.5-1 and 1-5 μM, respectively).1It inhibits the growth of U2OS osteosarcoma cells (IC50= ~2.5 μM) in a p53-dependent mannerviainduction of SESN2 and subsequent inhibition of mTORC1. YW3-56 (10 mg/kg) reduces tumor growth in an S-180 murine sarcoma tumor model. It also inhibits tumor growth in the 1883 MDA-MB-231 breast cancer bone metastasis mouse xenograft model.2 1.Wang, Y., Li, P., Wang, S., et al.Anticancer pept...

化合物

Synonym: GSK-121,GSK 121

Cl-amidine hydrochloride

Cat.No: T10831L

Synonym:

Target: Apoptosis, PAD

GSK484 hydrochloride

Cat.No: TQ0067

Synonym: GTPL8577,AOB6992,GSK484盐酸盐

YW3-56 (hydrochloride) (technical grade)

Cat.No: T36108

Synonym: YW3-56 (hydrochloride) (technical grade)

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T2205	Acefylline Theophylline-7-acetic acid,茶碱乙酸,Carboxymethyltheophylline,acetyloxytheophylline,Theophyllineacetic acid	TNF; PAD; PKA; HDAC; PDE; Adenosine Receptor	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience; Tyrosine Kinase/Adaptors
	Acefylline (Theophylline-7-acetic acid) 是黄嘌呤衍生物，是一种腺苷受体拮抗剂。它是蛋白质精氨酸脱亚氨酶 (PAD) 激活剂，也是一种支气管扩张剂，可抑制大鼠肺 cAMP 磷酸二酯酶同工酶。